Palabras clave
Cistatina C
daño renal
cardiopatía
ensayo enzimatico
daño renal
cardiopatía
ensayo enzimatico
Cómo citar
Mendoza, E., Pico, B., & Castro Jalca, J. (2024). Cistatina c y su utilidad en el diagnóstico de enfermedad renal y otras afectaciones en la población. Conocimiento Global, 9(2), 470-486. https://doi.org/10.70165/cglobal.v9i2.516
Resumen
La cistatina C es una proteína pequeña producida por casi todas las células nucleadas del organismo. En los últimos años ha recibido mucha atención como biomarcador de la función renal y ha demostrado ser útil en el diagnóstico de enfermedades renales y otras afecciones. El objetivo del estudio fue analizar cistatina C y su utilidad en el diagnóstico de enfermedad renal y otras afectaciones en la población. La metodología aplicada fue de revisión narrativa documental de carácter exploratorio y nivel explicativo. Los principales resultados revelaron que en general con la variable de sexo en la población femenina en estado patológico los niveles son superiores a la de los hombres; Los métodos más comunes son el inmunoensayo turbidimétrico y la inmunonefelometría son los métodos más comúnmente utilizados para la medición de cistatina C los valores de sensibilidad varían del 51% al 92%, mientras que la especificidad va del 61.54% al 90.6% Y concluyeron los rangos considerados normales para la cistatina C de entre hombres y mujeres tienden a ser muy diversos; La cistatina C se eleva en diversas condiciones patológicas, no limitándose solo a la enfermedad renal crónica; El inmunoensayo turbidimétrico y la inmunonefelometría son los métodos más comúnmente utilizados para la medición de cistatina C.
Citas
Adingwupu, O. M., Barbosa, E. R., Palevsky, P. M., Vassalotti, J. A., Levey, A. S., & Inker, L. A. (2023). Cystatin C as a GFR Estimation Marker in Acute and Chronic Illness: A Systematic Review. Kidney Medicine, 5(12), 100727. https://doi.org/10.1016/J.XKME.2023.100727
Barreto, E. F., Rule, A. D., Murad, M. H., Kashani, K. B., Lieske, J. C., Erwin, P. J., Steckelberg, J. M., Gajic, O., Reid, J. M., & Kane-Gill, S. L. (2019). Prediction of the Renal Elimination of Drugs With Cystatin C vs Creatinine: A Systematic Review. Mayo Clinic Proceedings, 94(3), 500–514. https://doi.org/10.1016/J.MAYOCP.2018.08.002
Bikkarolla, S. K., Venkatesan, K., Revathy, Y. R., Parameswaran, S., Krishnakumar, S., & Dendukuri, D. (2024). The Quantitative Detection of Cystatin-C in Patient Samples Using a Colorimetric Lateral Flow Immunoassay. Biosensors, 14(1). https://doi.org/10.3390/BIOS14010030/S1
Bjornstad, P., Karger, A. B., & Maahs, D. M. (2018). Measured GFR in Routine Clinical Practice – The Promise of Dried Blood Spots. Advances in Chronic Kidney Disease, 25(1), 76. https://doi.org/10.1053/J.ACKD.2017.09.003
Cancho, B., Alvarez Lopez, A., Valladares, J., Rodriguez Sabillon, J. A., Lopez Gomez, J., & Robles, N. R. (2024a). Prognostic value of isolated high serum cystatin C levels without glomerular filtration rate reduction. Medicina Clínica (English Edition), 162(11), 511–515. https://doi.org/10.1016/J.MEDCLE.2023.12.012
Cancho, B., Alvarez Lopez, A., Valladares, J., Rodriguez Sabillon, J. A., Lopez Gomez, J., & Robles, N. R. (2024b). Valor pronóstico de la elevación aislada de los niveles de cistatina C sin reducción del filtrado glomerular. Medicina Clínica, 162(11), 511–515. https://doi.org/10.1016/J.MEDCLI.2023.12.015
Chen, D. C., Potok, O. A., Rifkin, D., & Estrella, M. M. (2022). Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR. Kidney360, 3(10), 1807–1814. https://doi.org/10.34067/KID.0003202022
Chen, Z., Zhang, J., Feng, J., Zhou, G., Jin, X., & Pan, J. (2021). Higher serum level of Cystatin C: An additional risk factor of CAD. Medicine, 100(2), E24269. https://doi.org/10.1097/MD.0000000000024269
Edinga-Melenge, B. E., Yakam, A. T., Nansseu, J. R., Bilong, C., Belinga, S., Minkala, E., Noudjeu, P. A., Ondhoua, M., Kokola, S. W., Ama Moor, V. J., & Ashuntantang, G. (2019a). Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population. BMC Clinical Pathology, 19(1). https://doi.org/10.1186/S12907-019-0086-7
Edinga-Melenge, B. E., Yakam, A. T., Nansseu, J. R., Bilong, C., Belinga, S., Minkala, E., Noudjeu, P. A., Ondhoua, M., Kokola, S. W., Ama Moor, V. J., & Ashuntantang, G. (2019b). Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population. BMC Clinical Pathology, 19(1). https://doi.org/10.1186/S12907-019-0086-7
Erlandsen, E. J., & Randers, E. (2018a). Reference intervals for plasma cystatin C and plasma creatinine in adults using methods traceable to international calibrators and reference methods. Journal of Clinical Laboratory Analysis, 32(6). https://doi.org/10.1002/JCLA.22433
Erlandsen, E. J., & Randers, E. (2018b). Reference intervals for plasma cystatin C and plasma creatinine in adults using methods traceable to international calibrators and reference methods. Journal of Clinical Laboratory Analysis, 32(6). https://doi.org/10.1002/JCLA.22433
Ge, J., Ji, Y., Wang, F., Zhou, X., Wei, J., & Qi, C. (2023). Correlation Between Cystatin C and the Severity of Cardiac Dysfunction in Patients with Systolic Heart Failure. Risk Management and Healthcare Policy, 16, 2419–2426. https://doi.org/10.2147/RMHP.S437678
Helmersson-Karlqvist, J., Lipcsey, M., Ärnlöv, J., Bell, M., Ravn, B., Dardashti, A., & Larsson, A. (2022). Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care. Heart, 108(4), 279–284. https://doi.org/10.1136/HEARTJNL-2020-318860
Ivey-Miranda, J. B., Inker, L. A., Griffin, M., Rao, V., Maulion, C., Turner, J. M., Wilson, F. P., Tang, W. H. W., Levey, A. S., & Testani, J. M. (2021). Cystatin C and Muscle Mass in Patients With Heart Failure. Journal of Cardiac Failure, 27(1), 48. https://doi.org/10.1016/J.CARDFAIL.2020.07.013
Kılıçkıran, H., Halilzade, İ., Halilzade, M. İ., Topçuoğlu, C., & Çınar, M. (2023). Role of cystatin C levels as an inflammatory marker in predicting endometriosis. Revista Da Associação Médica Brasileira, 69(12), 20230613. https://doi.org/10.1590/1806-9282.20230613
Larki, R. A., Jamali, B., Meidani, M., & Mousavi, S. (2018). Serum Cystatin C for Evaluation of Acute Kidney Injury in Adults Treated with Colistin. Journal of Research in Pharmacy Practice, 7(4), 178. https://doi.org/10.4103/JRPP.JRPP_18_53
Lasserson, D. S., Shine, B., James, T., & O’Callaghan, C. A. (2017a). Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study. The British Journal of General Practice, 67(663), e732. https://doi.org/10.3399/BJGP17X692585
Lasserson, D. S., Shine, B., James, T., & O’Callaghan, C. A. (2017b). Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study. British Journal of General Practice, 67(663), e732–e735. https://doi.org/10.3399/BJGP17X692585
Lees, J. S., Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K., Ebert, N., Mark, P. B., & Shlipak, M. G. (2022). Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease. JAMA Network Open, 5(10), e2238300–e2238300. https://doi.org/10.1001/JAMANETWORKOPEN.2022.38300
Lees, J. S., Welsh, C. E., Celis-Morales, C. A., Mackay, D., Lewsey, J., Gray, S. R., Lyall, D. M., Cleland, J. G., Gill, J. M. R., Jhund, P. S., Pell, J., Sattar, N., Welsh, P., & Mark, P. B. (2019). Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25(11), 1753–1760. https://doi.org/10.1038/S41591-019-0627-8
Li, Y., Yang, S., Peng, D., Zhu, H. M., Li, B. Y., Yang, X., Sun, X. L., & Zhang, M. (2020). Predictive value of serum cystatin C for risk of mortality in severe and critically ill patients with COVID-19. World Journal of Clinical Cases, 8(20), 4726. https://doi.org/10.12998/WJCC.V8.I20.4726
Lin, Y. L., Chang, I. C., Liou, H. H., Wang, C. H., Lai, Y. H., Kuo, C. H., & Hsu, B. G. (2021). Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease. Scientific Reports 2021 11:1, 11(1), 1–10. https://doi.org/10.1038/s41598-021-96447-9
Matuszewski, M., Reznikov, Y., Pruc, M., Peacock, F. W., Navolokina, A., Júarez-Vela, R., Jankowski, L., Rafique, Z., & Szarpak, L. (2022). Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 19(21). https://doi.org/10.3390/IJERPH192114607
Mindikoglu, A. L., Opekun, A. R., Mitch, W. E., Magder, L. S., Christenson, R. H., Dowling, T. C., Weir, M. R., Seliger, S. L., Howell, C. D., Raufman, J. P., Rana, A., Goss, J. A., Khaderi, S. A., & Vierling, J. M. (2018). Cystatin C is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis. Digestive Diseases and Sciences, 63(3), 665. https://doi.org/10.1007/S10620-017-4897-Z
Mooney, J. F., Croal, B. L., Cassidy, S., Lee, V. W., Chow, C. K., Cuthbertson, B. H., & Hillis, G. S. (2019). Relative value of cystatin C and creatinine-based estimates of glomerular filtration rate in predicting long-term mortality after cardiac surgery: a cohort study. BMJ Open, 9(9). https://doi.org/10.1136/BMJOPEN-2019-029379
Nateghi Haredasht, F., Viaene, L., Vens, C., Callewaert, N., De Corte, W., & Pottel, H. (2022). Comparison between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate in the Follow-Up of Patients Recovering from a Stage-3 AKI in ICU. Journal of Clinical Medicine, 11(24). https://doi.org/10.3390/JCM11247264
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Ziegelasch, N., Vogel, M., Müller, E., Tremel, N., Jurkutat, A., Löffler, M., Terliesner, N., Thiery, J., Willenberg, A., Kiess, W., & Dittrich, K. (2019a). Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage. Pediatric Nephrology (Berlin, Germany), 34(3), 449. https://doi.org/10.1007/S00467-018-4087-Z
Ziegelasch, N., Vogel, M., Müller, E., Tremel, N., Jurkutat, A., Löffler, M., Terliesner, N., Thiery, J., Willenberg, A., Kiess, W., & Dittrich, K. (2019b). Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage. Pediatric Nephrology, 34(3), 449–457. https://doi.org/10.1007/S00467-018-4087-Z/TABLES/3
Barreto, E. F., Rule, A. D., Murad, M. H., Kashani, K. B., Lieske, J. C., Erwin, P. J., Steckelberg, J. M., Gajic, O., Reid, J. M., & Kane-Gill, S. L. (2019). Prediction of the Renal Elimination of Drugs With Cystatin C vs Creatinine: A Systematic Review. Mayo Clinic Proceedings, 94(3), 500–514. https://doi.org/10.1016/J.MAYOCP.2018.08.002
Bikkarolla, S. K., Venkatesan, K., Revathy, Y. R., Parameswaran, S., Krishnakumar, S., & Dendukuri, D. (2024). The Quantitative Detection of Cystatin-C in Patient Samples Using a Colorimetric Lateral Flow Immunoassay. Biosensors, 14(1). https://doi.org/10.3390/BIOS14010030/S1
Bjornstad, P., Karger, A. B., & Maahs, D. M. (2018). Measured GFR in Routine Clinical Practice – The Promise of Dried Blood Spots. Advances in Chronic Kidney Disease, 25(1), 76. https://doi.org/10.1053/J.ACKD.2017.09.003
Cancho, B., Alvarez Lopez, A., Valladares, J., Rodriguez Sabillon, J. A., Lopez Gomez, J., & Robles, N. R. (2024a). Prognostic value of isolated high serum cystatin C levels without glomerular filtration rate reduction. Medicina Clínica (English Edition), 162(11), 511–515. https://doi.org/10.1016/J.MEDCLE.2023.12.012
Cancho, B., Alvarez Lopez, A., Valladares, J., Rodriguez Sabillon, J. A., Lopez Gomez, J., & Robles, N. R. (2024b). Valor pronóstico de la elevación aislada de los niveles de cistatina C sin reducción del filtrado glomerular. Medicina Clínica, 162(11), 511–515. https://doi.org/10.1016/J.MEDCLI.2023.12.015
Chen, D. C., Potok, O. A., Rifkin, D., & Estrella, M. M. (2022). Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR. Kidney360, 3(10), 1807–1814. https://doi.org/10.34067/KID.0003202022
Chen, Z., Zhang, J., Feng, J., Zhou, G., Jin, X., & Pan, J. (2021). Higher serum level of Cystatin C: An additional risk factor of CAD. Medicine, 100(2), E24269. https://doi.org/10.1097/MD.0000000000024269
Edinga-Melenge, B. E., Yakam, A. T., Nansseu, J. R., Bilong, C., Belinga, S., Minkala, E., Noudjeu, P. A., Ondhoua, M., Kokola, S. W., Ama Moor, V. J., & Ashuntantang, G. (2019a). Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population. BMC Clinical Pathology, 19(1). https://doi.org/10.1186/S12907-019-0086-7
Edinga-Melenge, B. E., Yakam, A. T., Nansseu, J. R., Bilong, C., Belinga, S., Minkala, E., Noudjeu, P. A., Ondhoua, M., Kokola, S. W., Ama Moor, V. J., & Ashuntantang, G. (2019b). Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population. BMC Clinical Pathology, 19(1). https://doi.org/10.1186/S12907-019-0086-7
Erlandsen, E. J., & Randers, E. (2018a). Reference intervals for plasma cystatin C and plasma creatinine in adults using methods traceable to international calibrators and reference methods. Journal of Clinical Laboratory Analysis, 32(6). https://doi.org/10.1002/JCLA.22433
Erlandsen, E. J., & Randers, E. (2018b). Reference intervals for plasma cystatin C and plasma creatinine in adults using methods traceable to international calibrators and reference methods. Journal of Clinical Laboratory Analysis, 32(6). https://doi.org/10.1002/JCLA.22433
Ge, J., Ji, Y., Wang, F., Zhou, X., Wei, J., & Qi, C. (2023). Correlation Between Cystatin C and the Severity of Cardiac Dysfunction in Patients with Systolic Heart Failure. Risk Management and Healthcare Policy, 16, 2419–2426. https://doi.org/10.2147/RMHP.S437678
Helmersson-Karlqvist, J., Lipcsey, M., Ärnlöv, J., Bell, M., Ravn, B., Dardashti, A., & Larsson, A. (2022). Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care. Heart, 108(4), 279–284. https://doi.org/10.1136/HEARTJNL-2020-318860
Ivey-Miranda, J. B., Inker, L. A., Griffin, M., Rao, V., Maulion, C., Turner, J. M., Wilson, F. P., Tang, W. H. W., Levey, A. S., & Testani, J. M. (2021). Cystatin C and Muscle Mass in Patients With Heart Failure. Journal of Cardiac Failure, 27(1), 48. https://doi.org/10.1016/J.CARDFAIL.2020.07.013
Kılıçkıran, H., Halilzade, İ., Halilzade, M. İ., Topçuoğlu, C., & Çınar, M. (2023). Role of cystatin C levels as an inflammatory marker in predicting endometriosis. Revista Da Associação Médica Brasileira, 69(12), 20230613. https://doi.org/10.1590/1806-9282.20230613
Larki, R. A., Jamali, B., Meidani, M., & Mousavi, S. (2018). Serum Cystatin C for Evaluation of Acute Kidney Injury in Adults Treated with Colistin. Journal of Research in Pharmacy Practice, 7(4), 178. https://doi.org/10.4103/JRPP.JRPP_18_53
Lasserson, D. S., Shine, B., James, T., & O’Callaghan, C. A. (2017a). Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study. The British Journal of General Practice, 67(663), e732. https://doi.org/10.3399/BJGP17X692585
Lasserson, D. S., Shine, B., James, T., & O’Callaghan, C. A. (2017b). Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study. British Journal of General Practice, 67(663), e732–e735. https://doi.org/10.3399/BJGP17X692585
Lees, J. S., Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K., Ebert, N., Mark, P. B., & Shlipak, M. G. (2022). Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease. JAMA Network Open, 5(10), e2238300–e2238300. https://doi.org/10.1001/JAMANETWORKOPEN.2022.38300
Lees, J. S., Welsh, C. E., Celis-Morales, C. A., Mackay, D., Lewsey, J., Gray, S. R., Lyall, D. M., Cleland, J. G., Gill, J. M. R., Jhund, P. S., Pell, J., Sattar, N., Welsh, P., & Mark, P. B. (2019). Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25(11), 1753–1760. https://doi.org/10.1038/S41591-019-0627-8
Li, Y., Yang, S., Peng, D., Zhu, H. M., Li, B. Y., Yang, X., Sun, X. L., & Zhang, M. (2020). Predictive value of serum cystatin C for risk of mortality in severe and critically ill patients with COVID-19. World Journal of Clinical Cases, 8(20), 4726. https://doi.org/10.12998/WJCC.V8.I20.4726
Lin, Y. L., Chang, I. C., Liou, H. H., Wang, C. H., Lai, Y. H., Kuo, C. H., & Hsu, B. G. (2021). Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease. Scientific Reports 2021 11:1, 11(1), 1–10. https://doi.org/10.1038/s41598-021-96447-9
Matuszewski, M., Reznikov, Y., Pruc, M., Peacock, F. W., Navolokina, A., Júarez-Vela, R., Jankowski, L., Rafique, Z., & Szarpak, L. (2022). Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 19(21). https://doi.org/10.3390/IJERPH192114607
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