Applications of proteomics in the diagnosis of breast cancer: advances and limitations
https://orcid.org/0009-0003-5776-0289
Breast cancer is an extremely complex and heterogeneous disease that is characterized by uncontrolled growth of cells belonging to the breast tissue. It is essential to identify more sensitive biomarkers. A recent response has been the use of proteomics technology, which has provided excellent help in the characterization of new molecular biomarkers by measuring protein profiles. Analyze the application of proteomics in the diagnosis of breast cancer, its Advances and Limitations. To prepare the article, a bibliographic review was used based on research in highly relevant scientific journals, repositories and health databases such as Scopus, Embase, Science Direct, ProQuest, PubMed, Scielo, Medline. The reviewed documents provide information about the application of different proteomic techniques in the diagnosis of breast cancer, many of their advances, but also the limitations that arise throughout this study. Many of the laboratory tests that can be performed for the diagnosis and management of breast cancer are highlighted. The application of proteomics in the diagnosis of breast cancer has represented a promising advance towards the early and personalized detection of this disease.
Anca-Narcisa Neagu, Danielle Whitham, Emma Buonanno, Avalon Jenkins, Teodora Alexa-Stratulat, Bogdan Ionel Tamba, & Costel C Darie. (2021, September 15). Proteomics and its applications in breast cancer. PubMed Central. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493401/
Andrew Macklin, Shahbaz Khan, & Thomas Kislinger. (2020, May 24). Recent advances in mass spectrometry based clinical proteomics: applications to cancer research. Clinical Proteomic. https://doi.org/10.1186/s12014-020-09283-w
Barzaman, K., Karami, J., Zarei, Z., Hosseinzadeh, A., Kazemi, M. H., Moradi-Kalbolandi, S., Safari, E., & Farahmand, L. (2020). Breast cancer: Biology, biomarkers, and treatments. International Immunopharmacology, 84, 106535. https://doi.org/10.1016/J.INTIMP.2020.106535
Corti, G., Buchet, R., Magrini, A., Ciancaglini, P., Mebarek, S., & Bottini, M. (2024). The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer. Current Opinion in Physiology, 37, 100734. https://doi.org/10.1016/J.COPHYS.2023.100734
Diana Gutiérrez Campos. (2021, July). Tecnicas utilizadas en la proteomica. ResearchGate.
https://www.researchgate.net/publication/353170170_Monografia_-_Tecnicas_utilizadas_en_la_proteomica
Duffy, M. J., O’Donovan, N., McDermott, E., & Crown, J. (2016). Validated biomarkers: The key to precision treatment in patients with breast cancer. The Breast, 29, 192–201. https://doi.org/10.1016/J.BREAST.2016.07.009
Fadi M. Alkabban, Gopal Menon, & Troy Ferguson. (2024, February 25). Breast Cancer. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK482286/
García-Redondo, M., Pareja López, Á., López Ruiz, N., & Rodríguez Alonso, J. M. (2023). Cáncer de mama: nueva clasificación molecular. Revista de Senología y Patología Mamaria, 36(2), 100352. https://doi.org/10.1016/J.SENOL.2021.04.002
Jayanti Mishra, Bhumika Kumar, Monika Targhotra, & P. K. Sahoo. (2020, October 27). Advanced and futuristic approaches for breast cancer diagnosis. SpringerOpen. https://fjps.springeropen.com/articles/10.1186/s43094-020-00113-2
Klára Brožová, Brigitte Hantusch, Lukas Kenner, & Klaus Kratochwill. (2023, February 20). Spatial Proteomics for the Molecular Characterization of Breast Cancer. Proteomes. https://doi.org/10.3390/proteomes11020017
Lee, Y., Ni, J., Beretov, J., Wasinger, V. C., Graham, P., & Li, Y. (2023). Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis. Molecular Cancer, 22(1). https://doi.org/10.1186/s12943-023-01741-x
Mardamshina, M., & Geiger, T. (2017). Next-Generation Proteomics and Its Application to Clinical Breast Cancer Research. The American Journal of Pathology, 187(10), 2175–2184. https://doi.org/10.1016/J.AJPATH.2017.07.003
Michael A. Gillette, Connie R. Jimenez, & Steven A. Carr. (2024, February 23). Clinical Proteomics: A Promise Becoming Reality. PubMed Central. https://doi.org/10.1016/j.mcpro.2023.100688
Oleg Tutanov, Ksenia Proskura, Roman Kamyshinsky, Tatiana Shtam, Yuri Tsentalovich, & Svetlana Tamkovich. (2022, October 27). Proteomic Profiling of Plasma and Total Blood Exosomes in Breast Cancer: A Potential Role in Tumor Progression, Diagnosis, and Prognosis. Frontiers in Oncology. https://doi.org/10.3389/fonc.2020.580891
Rodrigo Reyes Hernández, & Laura Pimentel Salazar. (2022, January). ¡Proteínas al descubierto! Un vistazo biotecnológico a la proteómica mundial y nacional. ResearchGate. https://www.researchgate.net/publication/378115768_Proteinas_al_descubierto_Un_vistazo_biotecnologico_a_la_proteomica_mundial_y_nacional
Rui An, Haitao Yu, Yanzhong Wang, Jie Lu, Yuzhen Gao, Xinyou Xie, & Jun Zhang. (2022, August 22). Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer. Cancer & Metabolism. https://doi.org/10.1186/s40170-022-00289-6
World Health Organization. (2024, March 13). Breast cancer. WHO. https://www.who.int/news-room/fact-sheets/detail/breast-cancer
Yang Woo Kwon, Han-Seul Jo, Sungwon Bae, Youngsuk Seo, Parkyong Song, Minseok Song, & Jong Hyuk Yoon. (2021, September 21). Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery. Frontiers in Medicine. https://doi.org/10.3389/fmed.2021.747333
Zeidan, B. A., Townsend, P. A., Garbis, S. D., Copson, E., & Cutress, R. I. (2015). Clinical proteomics and breast cancer. The Surgeon, 13(5), 271–278. https://doi.org/10.1016/J.SURGE.2014.12.003
Zhu, Z., Lai, J., & Ding, X. (2023, August 18). Advancing Breast Cancer Heterogeneity Analysis: Insights from Genomics, Transcriptomics and Proteomics at Bulk and Single-Cell Levels. ProQuest. https://www.proquest.com/docview/2856927403/9B73E8E65CB54864PQ/19?sourcetype=Scholarly%20Journals