Identification of inmunogenic antibodies by blood systems in the population
http://orcid.org/0000-0003-1400-307X
Immunogenic antibodies play a critical role in transfusion medicine, organ transplantation, and the treatment of autoimmune diseases, identifying them in the population is crucial to ensure compatibility in transfusions and transplants, as well as to understand the pathogenesis of these diseases. The objective of the study was to demonstrate immunogenic antibodies by blood systems in the population. The methodology applied was descriptive documentary narrative, which allowed the selection of articles related to the topic. The results highlighted that the immunogenic antibodies according to the geographical area of greatest frequency were Duffy and Kidd, reaching 79.66 and 50% respectively. Prevalence shows a great variability, from 7.7% in children in Japan to 66.9% in children in Saudi Arabia's Asian regions. A variety of techniques are used, including antiglobulin testing, genotyping, PCR-SSP, and cell panels. In conclusion, Duffy showed remarkably different frequencies in different populations. The prevalence varies in age groups, with younger children being the most affected. To identify irregular antibodies, several techniques were used, including PCR-SSP, cell panels, and cross-testing.
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